I ran a case by GPT5-Pro from our 89,000-strong physician facebook group yesterday. A cardiologist (yes, a cardiologist) was having trouble determining the cause of a patient’s uncontrolled hypertension (range over 200mmHg Systolic). It was a very long write-up of every medication combo he had tried, every test and intervention done, and that he had run up against a wall. GPT5-Pro put out an incredible, well organized, prioritized list of actions to take and differential diagnoses to consider. It indicated why it had prioritized the diagnoses and testing based on the patient’s history, family history, and response to medications. It indicated which suggestions were directly from the guidelines from various societies. The GPT5-Pro product was as if the best sub specialist at the speciality centers like Mayo, had been given this case to look at. And it did it in under 15 minutes with no additional patient travel or visits. The GPT5-Pro output covered every suggestion in the comments of various physicians but framed each one by priority and logic instead of single disorganized suggestions. Once again, it hit a home run on a very difficult case.
How People Are Using AI For Clinical Diagnosis
Doctors and patients are now throwing hard cases at frontier models (e.g., GPT-5 Pro) and reporting striking hits—from photo-plus-symptom identifications to prioritized differentials that read like a top subspecialist’s note. The vibe in user stories is awed and practical (“it cracked what stumped us for months”), while experts project a sharper, more split energy: some point to validated wins (sepsis triage, retina-based lupus), agentic systems claiming big accuracy gains, and med-school curricula catching up; others flag nuance—RCTs where “AI alone” beats clinicians but adding it didn’t help, and reminders that diagnosis may soon be commoditized while judgment and management remain the real game. Net: in 2025, AI is moving from clever consult to co-diagnostician—powerful, faster, often right—but still demanding guardrails, evidence, and human stewardship.
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I just want to say this: GPT-5 Pro is simply incredible in healthcare! I am working with a physician friend to test several very difficult cases, including one that took months to diagnose and required pathology. Pro gave the correct answer from just a photo and a few symptoms!